Studier viser at B12 virker direkte på epifysen slik at den provoserer en raskere frisetting av melatonin på natten som tilbakstiller søvn-våken cyklus. B12 forårsaker også at melatoninet slik at det forsvinner raskere på morgenen. Svært alvorlige søvn-våken sykdommer har med stor fremgang blitt behandlet med vitamin B12 i metylkobalamin form, selv om det kanskje ikke fungerer for alle.


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Vitamin B12 References

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References

Adachi S, Kawamoto T, Otsuka M, et al. Enteral vitamin B12 supplements reverse postgastrectomy B12 deficiency. Ann Surg. 2000; 232:199-201.

Araki A, et al. 1993. Plasma homocysteine concentrations in Japanese patients with non-insulin-dependent diabetes mellitus: effect of parenteral methylcobalamin treatment. Atherosclerosis 103(2):149-57.

Baik HW, Russell RM. Vitamin B12 deficiency in the elderly. Annu Rev Nutr. 1999; 19:357-377 Battersby AR. How nature builds the pigments of life: The conquest of vitamin B12. Science. 1994; 264:1551-1557.

Bauman WA, Shaw S, Jayatilleke E, Spungen AM, Herbert V. Increased intake of calcium reverses vitamin B12 malabsorption induced by metformin. Diabetes Care. 2000; 23:1227-1231.

Berlin R, et al. 1978. Vitamin B12 body stores during oral and parenteral treatment of pernicious anaemia. Acta Med Scand 204(1-2):81-4.

Bernard MA, et al. 1998. The effect of vitamin B12 deficiency on older veterans and its relationship to health [see comments]. J Am Geriatr Soc 46(10):1199-206.

Bottiglieri T. Folate, vitamin B12, and neuropsychiatric disorders. Nutr Rev. 1996; 54:382-390.

Butzkueven H, King JO. Nitrous oxide myelopathy in an abuser of whipped cream bulbs. J Clin Neurosci. 2000; 7:73-75.

Carmel R. Subtle cobalamin deficiency. Ann Intern Med. 1996; 124:338-339.

Carmel R, Gott PS, Waters CH, et al. The frequency of low cobalamin levels in dementia usually signify treatable metabolic, neurologic and electrophysiologic abnormalities. Eur J Haematol. 1995; 54:245-253.

Choi S-W. Vitamin B12 deficiency: A new risk factor for breast cancer? Nutr Rev. 1999; 57:250-253.

Clarke R, Smith AD, Jobst KA, Refsum H, Sutton L, Ueland PM. Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer's disease. Arch Neurol. 1998; 55:1449-1455.

Dagnelie PC, van Staveren WA, van den Berg H. Vitamin B12 from algae appears not to be bioavailable. Am J Clin Nutr. 1991; 53:695-697.

Delpre G, Stark P, Niv Y. Sublingual therapy for cobalamin deficiency as an alternative to oral and parenteral cobalamin supplementation. Lancet. 1999; 354:740-741.

Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington, DC: National Academy Press; 1998:306-356.

Donaldson, MS. Metabolic vitamin B12 status on a mostly raw vegan diet with follow-up using tablets, nutritional yeast, or probiotic supplements. Ann Nutr Metab. 2000;44:229-234.

Drennan CL, Huang S, Drummond JT, et al. How a protein binds B12: A 3.0 A X-ray structure of B12-binding domains of methionine synthase. Science. 1994; 266:1669-1674.

Elia M. Oral or parenteral therapy for B12 deficiency (commentary). Lancet. 1998;

352:1721-1722.
Ellenbogen L. Vitamin B12. In: Machlin LJ, ed. Handbook of Vitamins. New York, NY: Marcel Dekker, Inc; 1984:497-547.

Farquharson J, Adams JF. Conversion of hydroxo(aquo)co- balamin to sulfitocobalamin in the absence of light: a reaction of importance in the identification of the forms of vitamin B12, with possible clinical significance. Am J Clin Nutr. 1977; 30:1617-1622.

Fata FT, Herzlich BC, Schiffman G, Ast AL. Impaired antibody responses to pneumcoccal polysaccharide in elderly patients with low serum vitamin B12 levels. Ann Intern Med. 1996; 124:299-304.

Freeman AG. 1992. Cyanocobalamin-a case for withdrawal: discussion paper. J R Soc Med 85:686-7.

Funada U, Wada M, Kawata T, et al. Changes in CD4+CD8+/CD4-CD8+ ratio and humoral immune functions in vitamin B12-deficient rats. Int J Vitam Nutr Res. 2000; 70:167-171.

Harriman GR, Smith PD, Horne MK, et al. Vitamin B12 malabsorption in patients with acquired immunodeficiency syndrome. Arch Intern Med. 1989; 149:2039-2041.

Hashimoto S, Kohsaka M, Morita N, Fukuda N, Honma S, Honma K (December 1996). "Vitamin B12 enhances the phase-response of circadian melatonin rhythm to a single bright light exposure in humans". Neurosci. Lett. 220 (2): 129-32. doi:10.1016/S0304-3940(96)13247-X. PMID 8981490. http://linkinghub.elsevier.com/retri...0439409613247X.

Heimburger DC, Alexander CB, Birch R, et al. Improvement in bronchial squamous metaplasia in smokers treated with folate and vitamin B12. Report of a preliminary randomized, double-blind intervention trial. JAMA. 1988; 259:1525-1530.

Higginbottom MC, Sweetman L, Nyhan WL. A syndrome of methylmalonic aciduria, homocystinuria, megaloblastic anemia and neurological abnormalities in a vitamin B12-deficient breast-fed infant of a strict vegetarian. N Eng J Med. 1978; 299:317-323.

Honma K, et al. 1992. Effects of vitamin B12 on plasma melatonin rhythm in humans: increased light sensitivity phase-advances the circadian clock? Experientia 48:716-20.

Houeto P, Hoffman JR, Imbert M, et al. Relation of blood cyanide to plasma cyanocobalamin concentration after a fixed dose of hydroxycobalamin in cyanide poisoning. Lancet. 1995; 346:605-608.

Houston DK, Johnson MA, Nozza RJ, et al. Age-related hearing loss, vitamin B12, and folate in elderly women. Am J Clin Nutr. 1999; 69:564-571.

Jacobsen DW, Simon RA, Singh M. Sulfite oxidase deficiency and cobalamin protection in sulfite sensitive asthmatics. J Allergy Clin Immunol. 1984; 73(Suppl):135.

Kaji R, et al. 1998. Effect of ultra high-dose methylcobalamin on compound muscle action potentials in amyotrophic lateral sclerosis: a double-blind controlled study. Muscle Nerve 21:1775-8.

Kamgar-Parsi B, et al. 1983. Successful treatment of human non-24-hour sleep-wake syndrome. Sleep 6:257-64.

Kaptan K, Beyan C, Ural AU, et al. Helicobacter pylori-is it a novel causative agent in Vitamin B12 deficiency? Arch Int Med. 2000; 160:1349-1353.

Kozyraki R, Fyfe J, Kristiansen M, et al. The intrinsic factor-vitamin B12 receptor, cabilin, is a high-affinity apolipoprotein A-1 receptor facilitating endocytosis of high-density lipoprotein. Nat Med. 1999; 5:656-661.

Kristiansen M, Kozyraki R, Jacobsen C, et al. Molecular dissection of the intrinsic factor-vitamin B12 receptor, cubilin, discloses regions important for membrane association and ligand binding. J Biol Chem. 1999; 274:20540-20544.

Kuzuminski AM, Del Giacco EJ, Allen RH, Stabler SP, Lindenbaum J. Effective treatment of cobalamin deficiency with oral cobalamin. Blood. 1998; 92:1191-1198.

Laine L, Ahnen D, McClain C, et al. Review article: potential gastrointestinal effects of long-term acid suppression with proton pump inhibitors. Aliment Pharmacol Ther. 2000; 14:651-668.

Langdon FW. Nervous and mental manifestations of pre-pernicious anemia. JAMA. 1905; 45:1635-1638.

Lindenbaum J, Healton EB, Savage DG, et al. Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis. N Engl J Med. 1988; 318:1720-1728.

Lindstedt G. [Nitrous oxide can cause cobalamin deficiency. Vitamin B12 is a simple and cheap remedy]. [Article in Swedish]. Lakartidningen. 1999; 96:4801-4805.

Mayer G, et al. 1996. Effects of vitamin B12 on performance and circadian rhythm in normal subjects. Neuropsychopharm 15:456-464.

McCaddon A, Kelly CL. Familial Alzheimer's disease and vitamin B12 deficiency. Age Ageing. 1994; 23:334-337.

Nilsson-Ehle H. Age-related changes in cobalamin (vitamin B12) handling. Implications for therapy. Drugs Aging. 1998; 12:277-292.

Norris, Jack, RD. "B12 in Tempeh, Seaweeds, Organic Produce, and Other Plant Foods". VeganHealth.org. http://www.veganhealth.org/b12/plant. Retrieved on 2008-01-17.

Okawa M, Takahashi K, Egashira K, et al. Vitamin B12 treatment for delayed sleep phase syndrome. Psychiatry Clin Neurosci. 1997; 51:275-279.

Ostreicher DS. Vitamin B12 supplements as protection against nitrous oxide inhalation. NY State Dent J. 1994; 60:47-49.

Parnetti L, et al. 1992. Platelet MAO-B activity and vitamin B12 in old age dementias. Mol Chem Neuropathol 16(1-2):23-32.

Rosener M, Dichgans J. Severe combined degeneration of the spinal cord after nitrous oxide anaesthesia in a vegetarian. J Neurol Neurosurg Psychiatry. 1996; 60:354.

Salom IL, et al. Effect of cimetidine on the absorption of vitamin B12. 1982. Scand J Gastroenterol 17(1):129-31.

Scalabrino G, Tredici G, Buccellato FR, Manfridi A. Further evidence for the involvement of epidermal growth factor in the signaling pathway of vitamin B12 (cobalamin) in the rat central nervous system. J Neuropathol Exp Neurol. 2000; 59:808-814.

Stubbe J. Binding site of nature's most beautiful cofactor. Science. 1994; 266:1663-1664.

Sumner AE, Chin MM, Abrahm JL, et al. Elevated methylmalonic acid and total homocysteine levels show high prevalence of vitamin B12 deficiency after gastric surgery. Ann Int Med. 1996; 124:469-476.

Shane B, et al. 1985. Vitamin B12--folate interrelationships. Ann Rev Nutr 5:115-41.

van Asselt DZ, et al. 1998. Role of cobalamin intake and atrophic gastritis in mild cobalamin deficiency in older Dutch subjects [see comments]. Am J Clin Nutr 68(2):328-34.

van Asselt DZ, Blom HJ, Zuiderent R, et al. Clinical significance of low cobalamin levels in older hospital patients. Neth J Med. 2000; 57:41-49.

Walsh, Stephen, RD. "Vegan Society B12 factsheet". Vegan Society. http://www.vegansociety.com/food/nutrition/b12/. Retrieved on 2008-01-17.

Watanabe T, et al. 1994. Ultra-high dose methylcobalamin promotes nerve regeneration in experimental acrylamide neuropathy. J Neurol Sci 122:140-3

Watanabe F, Katsura H, Takenaka S, et al. Pseudovitamin B12 is the predominant cobamide of an algal health food, spirulina tablets. J Agric Food Chem. 1999; 47:4736-4741.

Weir DG, Scott JM. Brain function in the elderly: role of vitamin B12 and folate. Br Med Bull. 1999; 55:669-682.

Weir DG, Scott JM. Vitamin B12 "Cobalamin." In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD; Williams and Wilkins; 1999:447-458.

Yamazaki K, et al. 1994. Methylcobalamin (methyl-B12) promotes regeneration of motor nerve terminals degenerating in anterior gracile muscle of gracile axonal dystrophy (GAD) mutant mouse. Neurosci Lett 170:195-7.